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Studies have found that whole blood exchange may provide disease-modifying therapy for Alzheimer’s disease.

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According to a new study by UTHealth Houston, new disease-modifying therapies for Alzheimer’s disease may include whole blood exchange, which effectively reduces the formation of amyloid plaques in the mouse brain.

The research team, led by Dr. Claudio Soto, senior author of the Department of Neurology at the University of Texas Health Sciences, was an associate professor of the department in collaboration with lead author Dr. Akihiko Urayama. A series of whole blood exchange therapies that partially replace the blood of mice showing amyloid precursor protein that causes Alzheimer’s disease with the complete blood of healthy mice of the same genetic background. The results of the study are today Molecular psychiatry..

“This article uses techniques commonly used in the medical field, such as plasma exchange and hemodialysis, to” purify “the blood of patients with Alzheimer’s disease. Hazardous substance Soto, director of the George and Cynthia Mitchell Center for Alzheimer’s Disease and related brain disorders and a prominent chairman of the Huffington Foundation in Neurology at McGovern Medical College, said: It circulates instead of the brain. “

Previous studies by Soto and other UT Health Houston researchers have shown that misfolding, aggregation, and accumulation of amyloid beta proteins in the brain play a central role in Alzheimer’s disease. Therefore, prevention and removal of misfolded protein aggregates is considered a promising treatment for this disease.

However, treatment of Alzheimer’s disease has long been complicated by the difficulty of delivering therapeutic agents across the blood-brain barrier. Through the latest research, Urayama, Soto et al. Discovered that manipulating the circulating components of Alzheimer’s disease may be the key to solving this problem.

“The blood vessels in the brain are classically considered to be the most impervious barrier in the body,” Urayama said. “We recognize that the barrier is at the same time a very special interface between the brain and the systemic circulation.”

After multiple transfusions, researchers found a 40% to 80% reduction in the incidence of brain amyloid plaques in a transgenic mouse model of Alzheimer’s disease. This reduction also resulted in improved spatial memory capacity of aged mice with amyloid lesions, slowing the rate of plaque growth over time.

The exact mechanism by which this blood exchange reduces amyloid’s condition and improves memory is currently unknown, but there are multiple possibilities. One possible reason is that lowering the amyloid beta protein in the bloodstream may help promote peptide redistribution. brain around there. Another theory, among other potential explanations, is that blood exchange somehow prevents the influx of amyloid beta or inhibits the reuptake of removed amyloid beta.

However, regardless of the mechanism of action associated with blood exchange therapy, this study shows that the target for Alzheimer’s disease treatment may be peripheral.


The theory of blood-brain barrier damage in Alzheimer’s disease may pave the way for new treatments


For more information:
Prophylactic and therapeutic reduction of amyloid deposition and behavioral disorders in a mouse model of Alzheimer’s disease by whole blood exchange, Molecular psychiatry (2022). DOI: 10.1038 / s41380-022-01679-4

Quote: Whole blood exchange may provide disease-modifying therapy for Alzheimer’s disease, studies (14 July 2022) at https://medicalxpress.com/news/2022-07-blood-exchange-disease Obtained July 14, 2022 from -modifying-therapy-alzheimer.html

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Studies have found that whole blood exchange may provide disease-modifying therapy for Alzheimer’s disease.

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