Studies identify how COVID-19 is associated with cognitive deficits such as Alzheimer’s disease

PET scan of the brain of a person with Alzheimer’s disease.Credit: public domain

A new study led by the Cleveland Clinic has identified a mechanism by which COVID-19 leads to dementia similar to Alzheimer’s disease.Survey results announced in Research and treatment of Alzheimer’s disease, COVID-19 shows a duplication of brain changes common in Alzheimer’s disease and may be useful in risk management and treatment strategies for COVID-19-related cognitive impairment.

Reports of neurological complications in COVID-19 and “long-distance transport” patients have generally persisted after infection has been resolved, causing SARS-CoV-2 (COVID-19). Virus) Brain functionHowever, it is not yet well understood how the virus leads to neurological problems.

“Several studies suggest that SARS-CoV-2 is infected, Brain cells Directly, no one else found evidence of the virus in the brain, “said Dr. Feixiong Cheng, an assistant staff member at the Cleveland Clinic’s Institute for Genomic Medicine and the lead author of the study. It is important to develop effective preventive and therapeutic strategies to address the outbreak of neurocognitive impairment that is expected to occur in the near future. “

In this study, researchers used artificial intelligence using existing datasets of patients with Alzheimer’s disease and COVID-19. They measured the proximity of SARS-CoV-2 host genes / proteins to genes / proteins associated with several neurological disorders. Researchers also Genetic factors This has made it possible for SARS-COV-2 to infect brain tissues and cells.

Researchers found little evidence that the virus was directly targeting the brain, but found a close network of the virus with genes / proteins associated with some neurological disorders, especially Alzheimer’s disease. To further investigate this, they show the neurological inflammation and cerebral microvascular injury that are characteristic of Alzheimer’s disease and the potential for COVID-19. I investigated the relationship.

“We have found that SARS-CoV-2 infection significantly alters Alzheimer’s disease markers involved in brain inflammation, and that certain viral entry factors are highly expressed in cells of the blood-brain barrier,” Dr. Chen explained. did. “These findings affect several genes or pathways in which the virus is involved in neuroinflammation, brain Microvascular damage that can lead to cognitive impairment such as Alzheimer’s disease. “

Researchers also found that individuals with the allele APOE E4 / E4, the greatest genetic risk factor for Alzheimer’s disease, had reduced expression of antiviral defense genes.

“Ultimately, we hope to pave the way for research that will lead to testable and measurable biomarkers that can identify patients at greatest risk of neurological complications from COVID-19,” said Chen. The doctor says.

Dr. Chen and his team are now using state-of-the-art network medicine and artificial intelligence technology to perform COVID-19-related neurological problems related to COVID-19. We are working to identify possible biomarkers and new therapeutic targets.

Researchers explore the link between the “Alzheimer’s disease gene” and COVID-19

For more information:
Yadi Zhou et al., Network Medicine has linked SARS-CoV-2 / COVID-19 infection to microvascular injury and neuroinflammation of the brain in cognitive impairment such as dementia. Research and treatment of Alzheimer’s disease (2021). DOI: 10.1186 / s13195-021-00850-3

Provided by
Cleveland Clinic

Quote: A study identified how COVID-19 is associated with cognitive deficits such as Alzheimer’s disease (June 10, 2021) Dementia.html

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Studies identify how COVID-19 is associated with cognitive deficits such as Alzheimer’s disease

Source link Studies identify how COVID-19 is associated with cognitive deficits such as Alzheimer’s disease

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