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Studies investigate why certain brain neurons are vulnerable to degeneration

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A study led by a neuroscientist at Ohio State University School of Medicine provides insights into the mechanisms that underpin selective neuronal fragility and provides insights into new therapies to prevent and treat Alzheimer’s disease and other neurodegenerative diseases. May be useful for development.

Survey results are published online in the journal Acta Neuropathologica..

“Understanding why some neurons in a particular brain region are so vulnerable to degeneration is Neurodegenerative diseaseHongjun “Harry” Fu, an assistant professor of neuroscience at Ohio State University School of Medicine, said: Tau pathology Grid cell dysfunction and spatial memory impairment. ”

Fu’s research focuses on understanding the subtypes of neurons that are vulnerable to the abnormal accumulation of tau protein aggregates in the brain that occur in the early stages of Alzheimer’s disease. His research also explores the molecular and cellular mechanisms underlying selective neuronal fragility.

Tau protein helps stabilize the internal skeleton of neurons in the brain. This internal skeleton has a tubular shape in which nutrients and other essential substances travel to reach different parts of the neuron. In Alzheimer’s disease, abnormally shaped tau protein accumulates and the internal skeleton collapses. This correlates well with neuronal cell death and memory loss.

Wolflamin is a protein encoded by the WFS1 gene in humans. This study found that excitatory neurons expressing wolflamin (WFS1) are more vulnerable in parts of the brain (the entorhinal cortex) that act as network hubs for memory, navigation, and time perception. I did.

Using both human postmortem brain tissue and mouse models, this study found that WFS1 tau through aberrant accumulation of tau protein aggregates and regulation of stress responses to the downstream proteolytic pathway, the autophagy-lysosomal pathway. It further shows that it may reduce the pathology and neurodegeneration of.

“We plan to further investigate the cell-type-specific role of WFS1 in Alzheimer’s disease and other neurodegenerative diseases. We are also exploring new drug targets aimed at promoting it, such as WFS1 and autophagy-lysosomal degradation promoters. Tau degradation and protection of vulnerable neurons in these catastrophic diseases. “

Fu collaborated with other researchers in the Department of Biochemistry and Pharmacology, Biomedical Informatics, Neuroscience, and Neurology at Ohio State University, and scientists at the National Children’s Hospital in Columbus. Nathan S. Kline Psychiatric Institute and Columbia University Medical Center are both located in New York. Washington University School of Medicine in St. Louis. Banner Sun Health Institute in Sun City, Arizona. Murdoch University in Perth, Australia. British Dementia Institute in London, UK.

“This key finding not only helps researchers better understand selective nerve and local fragility in Alzheimer’s disease and other neurodegenerative diseases, but also the WFS1 gene in Alzheimer’s disease and possibly other nerves. It suggests that it may be a therapeutic target for degenerative diseases, “Dr. Carol R. Bradford, Dean of the Ohio State University of Medicine.


Certain types of brain cells can cause Alzheimer’s disease


For more information:
Shuo Chen et al, Wolframin is a new regulator of tau pathology and neurodegeneration. Acta Neuropathologica (2022). DOI: 10.1007 / s00401-022-02417-4

Quote: The study found that certain brain neurons are vulnerable to degeneration (April 11, 2022) on April 11, 2022 at https://medicalxpress.com/news/2022-04-explores-brain. Obtained from -neurons-vulnerable-degeneration.html.

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Studies investigate why certain brain neurons are vulnerable to degeneration

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