Studies reveal how air pollution can increase the risk of cardiovascular disease

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Small particles of air pollution, called particulate matter, can have a variety of health effects, and exposure to high levels is a known risk factor for cardiovascular disease. A new study led by researchers at Massachusetts General Hospital (MGH) has a detrimental effect on cardiovascular health by activating the production of inflammatory cells in the bone marrow and ultimately causing arterial inflammation. It is clear to give.The survey results are published in European Heart Journal..

The retrospective study included 503 patients without cardiovascular disease or cancer who underwent MGH imaging for a variety of medical reasons. Scientists used data from the US Environmental Protection Agency’s Air Quality Monitor closest to each participant’s address to estimate an average annual particulate matter level for each participant.

With a median follow-up of 4.1 years, 40 people experienced major cardiovascular events such as heart attack and stroke, with participants at high risk having high levels of particulate matter at their home address. It was. Their risk increased even after considering cardiovascular risk factors, socioeconomic factors, and other major confounding factors. Imaging tests to assess the condition of internal organs and tissues have shown that these participants also have high bone marrow activity, increased production of inflammatory cells (a process called white blood cell production), and increased inflammation of the arteries. It was. Additional analysis revealed that leukocyte production in response to exposure to air pollution was the trigger for arterial inflammation.

“The pathways linking exposure to air pollution to cardiovascular events through higher myeloid activity and arterial inflammation accounted for 29% of the association between air pollution and cardiovascular disease events,” said MGH cardiovascular imaging. Fellow co-lead author Shady Abohashem, MD, said. .. “These findings suggest that air pollution exposure is an unrecognized risk factor for cardiovascular disease, a treatment that goes beyond mitigation to mitigate the cardiovascular effects of air pollution exposure. It suggests a goal. “

Michael Osborne, MD, co-lead author of MGH cardiologists, explains that treatments that target increased inflammation after exposure to particulate matter may benefit patients who cannot avoid air pollution. doing. “Importantly, most of the population surveyed had air pollution exposure well below the unhealthy threshold established by the World Health Organization. This is because the level of air pollution is really safe. It suggests that it cannot be considered, “he says.

Studies have linked an intensive decrease in blood pressure to a reduced risk of CV in patients exposed to air pollution

For more information:
Ahmed Tawakol et al, Leukocyte formation underlying the association between human air pollution and cardiovascular disease-arterial axis, European Heart Journal, 2021; ehaa982, / 10.1093 / eurheartj / ehaa982

Provided by Massachusetts General Hospital

Quote: Research reveals how air pollution can increase the risk of cardiovascular disease (February 4, 2021).

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Studies reveal how air pollution can increase the risk of cardiovascular disease

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