Lifestyle

Surgery has a life-prolonging effect on male patients with stage IV breast cancer who receive systemic therapy

Benefits of surgical treatment in stage IV male breast cancer patients with known hormone receptor status. Credit: American College of Surgeons

Virtual American College of Surgeons (ACS) Clinical Conference 2021.

National Comprehensive Cancer Network Guidelines for Treating Stage IV Men chest cancer Recommended Systemic therapyKelly A. Stahl, a surgeon at Hershey’s Penn State University of Medicine, said the surgery is used to minimize symptoms such as ulcers, pain, and bleeding. However, new findings show that surgery has a life-prolonging effect on men with stage IV breast cancer, she said.

“Stage IV breast cancer in men is very disastrous and the notion that there is no survival benefit needs to be revisited. Surgical intervention“. Dr. Darilla G. Dodge, MD, general surgeon and co-author of the study at the Pennsylvania Milton S. Hershey Medical Center in Hershey, Pennsylvania, said.

“Best practices need to be revisited for this subgroup of patients who respond to systemic therapy and have less metastatic burden.”

According to Dr. Dodge, breast cancer in men accounts for less than 1% of all breast cancer cases, while 1 in 8 women has breast cancer compared to 1 in 1,000 men. As a result, men’s public awareness of breast cancer is low.

“We spent a whole month recognizing breast cancer for women, but it’s not well known that men can get it, and some men even have a genetic predisposition to get it. I have, “said Dr. Stahl.

Unfortunately, low public awareness contributes to the fact that 6% of women are not diagnosed with stage IV cancer compared to 10% of men. In addition, 40% of male breast cancer patients are not diagnosed until stage III or IV, even though breast cancer is easier. Male patient Dr. Dodge said to detect himself. “Awareness is important because men have a poorer prognosis if their diagnosis is delayed,” she added.

Researchers Kelly a Stahl, MD, Penn State College of Medicine, Hershey, and Darilla G. Dodge, MD, FACS, Penn State Health Milton S. Hershey Medical Center I will explain. Credit: American College of Surgeons

About research

The authors were amazed at how many patients could be found that fit the study parameters thanks to the extensive data set of the National Cancer Database (NCDB). Researchers identified 539 patients with stage IV breast cancer with known ER / PR status from 2004 to 2017 at NCDB. The chi-square test examined the differences in subgroups between the treatments received. Overall survival was assessed using the Kaplan-Meier method. The multivariate Cox proportional hazards model investigated factors related to survival.

Notable survival benefits

The researchers found a survival benefit in patients who received trimodal therapy compared to patients who received systemic therapy alone. ER-positive patients who underwent trimodal or systemic therapy and surgery had improved 5-year overall survival when compared to systemic therapy. PR-positive patients who underwent trimodal or systemic therapy and surgery had improved 5-year overall survival when compared to systemic therapy. The order of treatment is important and the greatest survival benefit is Neoadjuvant chemotherapy Compared to those who received adjuvant chemotherapy.

“We are trying to catch up to better coordinate the treatment of men. breast cancer This study shows how treatment can be adjusted for stage IV disease, “Dr. Dodge said.


Surgery may offer survival benefits in certain metastatic breast cancers


For more information:
Star KA, etc. Benefits of surgical treatment in stage IV male breast cancer patients with known hormone receptor status. American College of Surgeons Clinical Conference 2021.

Quote: Surgery for male stage IV breast cancer patients accepting systemic therapy (October 24, 2021) https: //medicalxpress.com/news/2021-10-surgery-survival-benefits-male to 2021 It has a life-prolonging effect acquired on October 24th. -stage.html

This document is subject to copyright. No part may be reproduced without written permission, except for fair transactions for personal investigation or research purposes. The content is provided for informational purposes only.



Surgery has a life-prolonging effect on male patients with stage IV breast cancer who receive systemic therapy

Source link Surgery has a life-prolonging effect on male patients with stage IV breast cancer who receive systemic therapy

Show More

Related Articles

Back to top button