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The choice of first treatment for prostate cancer does not affect mental health outcomes

Prostate cancer cells. Credit: NIH Image Gallery

Depression and other mental health outcomes are similar in men who have opted for different options for initial treatment of localized prostate cancer. Urology Journal..

“But our study identifies some features associated with reduced emotional well-being after initiation. Prostate cancer Treatments for older people, worsening overall health, and increased early-stage depressive symptoms, “commented Amy N. Luckenbo, lead author of the Vanderbilt University Medical Center in Nashville.

New data on mental health outcomes in the treatment of early-stage prostate cancer

Men with localized prostate cancer have initial treatment options.Previous studies show that these are Treatment options— Includes surgery, radiation therapy, or active surveillance — similar survival rates. They differ primarily in terms of treatment-related complications such as urinary symptoms and erectile dysfunction, and the intervention required to manage them.

Few studies have investigated how the choice of treatment for prostate cancer affects Mental health results.. “It’s a contrast Breast cancer Colorectal cancer.Studies show that sexual dysfunction and body image concerns are the cause Mental distress It is deteriorating psychosocial function. “

Researchers analyzed follow-up data from 2,742 men entering treatment for localized prostate cancer from an ongoing CEASAR study (comparative efficacy analysis of surgery and radiation for localized prostate cancer). did. About 52% of patients chose immediate surgery. 35% received Radiation therapyWith or without hormonal (androgen deprivation) therapy; 14% were actively monitored and closely monitored to delay treatment until signs of progression appeared.

After 5 years of follow-up, the patient completed a standard assessment of depression, emotional well-being, and energy / malaise. Other characteristics were adjusted to analyze differences between treatment groups.

The data showed that “there is no evidence of clinically meaningful treatment-related effects on the long-term assessment of depressive symptoms,” Dr. Luckenbaugh and co-authors write. In all treatment groups, the mean score for depressive symptoms remained low at initial assessment and at follow-up.

Baseline scores also showed good emotional well-being and energy / malaise scores for prostate cancer patients in this group. There were no “clinically meaningful” differences for men who chose surgery, radiation therapy (with or without hormone therapy), or active monitoring, with some differences.

However, the characteristics of other patients did affect mental health outcomes. Men with high early-stage depression scores were particularly likely to have worsening symptoms of depression. Depression was also more likely to worsen in patients with poor overall health, poor physical function, and less involvement. process Decision-making; The same is true for older, unmarried, low-income men. Many of the same factors predicted lower emotional well-being scores in addition to lower emotional support.

This analysis is the first prospective study of mental health outcomes in men with localized prostate cancer. Result is, Initial treatment It has nothing to do with depression, emotional well-being, energy / malaise during follow-up, and the characteristics of other patients are important predictors. “It is imperative that urologists seize the available opportunities to identify and intervene with patients with mental health concerns, both at diagnosis and during follow-up,” said Dr. Luckenbaugh and his colleagues. I conclude that.


Study: Prostate Cancer Treatment Regret


For more information:
Amy N. Luckenbaugh et al, Relationship between Treatment of Localized Prostate Cancer and Mental Health Results, Urology Journal (2022). DOI: 10.1097 / JU.0000000000002370

Quote: The choice of first treatment for prostate cancer does not affect mental health outcomes (March 3, 2022).

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The choice of first treatment for prostate cancer does not affect mental health outcomes

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