The dynamic heart model mimics hemodynamic loading and advances artificial heart tissue technology

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Efforts to understand the progression of heart disease and develop therapeutic tissues that can repair the human heart are only part of the focus of the Fineberg research group at Carnegie Mellon University. The group’s latest dynamic model, created in collaboration with Dutch collaborators, mimics the physiological burden on myocardial tissue engineering and sets a precedent for how genetics and mechanical forces contribute to myocardial function. Brings no view.

“Our laboratory has long been involved in human engineering and construction. heart Muscle tissue. This allows us to more accurately track how the disease manifests and create therapeutic tissue to repair and replace heart damage, “explains Adam Feinberg, a professor of biomedical engineering. Materials science And engineering. “One of the challenges is the need to build these small myocardiums in a Petri dish. We’ve done this for many years. In these in vitro systems, blood pressure causes the actual heart to look. Mechanical load. “

Hemodynamic loading, or preload (stretching the myocardium during chamber filling) and afterload (when the myocardium contracts), are not only important for healthy myocardial function, but can also contribute to the progression of heart disease. There is sex. Preload and afterload can cause maladapted changes in the myocardium, as in hypertension, myocardial infarction, and cardiomyopathy.

In a new study published in Scientific translation medicine, This group presents a system consisting of artificial myocardial tissue (EHT) attached to elastic strips designed to mimic physiological preload and afterload. This first model shows that recreating exercise-like loads promotes the formation of more functional myocardium, which is more organized and produces more force with each contraction. However, when using cells from patients with certain types of heart disease, these same exercise-like loads can cause myocardial dysfunction.

“One of the really important things in this work is group work “We have an arrhythmogenic cardiomyopathy (ACM) that is often exacerbated by exercise between our lab and our Dutch collaborators, including cardiovascular specialist Peter van der Mer. ) Treats patients with genetically related cardiovascular disease, including a type called. We were able to obtain patient-specific guidance. Pluripotent stem cells, Differentiate these into cardiomyocytes and then use them in a new EHT model to recreate ACM. Petri dish, So we can better understand it. “

Jacqueline Bliley, a graduate student in biomedical engineering and co-lead author of a recently published treatise, said: “To ensure the reproducibility of the study and to be able to compare the findings of this study around the world. Community is very important, “he added.

Looking to the future, collaborators will use models and discoveries to study a variety of other heart diseases with mutations, develop new treatments, and develop drugs to assess their effectiveness. Aiming to test.

“You can take lessons learned from assembling EHT on a plate to create a bigger heart. logic It can be used therapeutically.By combining these new results with previous work involving 3D bioprinting Myocardium (((Was announced in Science 2019), We hope that one day we will design and repair a functional tissue large enough to be transplanted. Human mind, “Feinberg projects.

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For more information:
Jacqueline M. Bliley et al, Human-manipulated dynamic loading of heart tissue enhances contractile function and promotes the phenotype of desmosome-related diseases. Scientific translation medicine (2021). DOI: 10.1126 / scitranslmed.abd1817

Quote: The dynamic heart model mimics hemodynamic loading and was obtained from on July 22, 2021. Advance Artificial Heart Tissue Technology (July 22, 2021)

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The dynamic heart model mimics hemodynamic loading and advances artificial heart tissue technology

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