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Third dose of COVID vaccine may boost immunity of transplant recipients-WUSF public media

Pharmacist Katie McDonough reconfigures the Pfizer-BioNTech vaccine when filling syringes at the UMass Memorial Healthcare COVID-19 Vaccination Center at the Mercantir Center in Worcester on April 22, 2021. Joseph Prezioso AFP

A small new study offers a faint hope that organ transplant recipients can be given a third dose of the COVID-19 vaccine to enhance their defense against coronavirus.

It’s important Previous studies show Almost half of organ transplant recipients showed no antibody response after two doses of Pfizer or modelna vaccine.

And even transplant recipients who responded antibody to vaccination were often more modest than those with a healthy immune system. Therefore, doctors advise these patients not to assume that vaccination is equivalent to immunity. According to the Scientific Registry of Transplant Recipients, more than 400,000 people in the United States have undergone organ transplants.

In a new study Published this week Annual report of internal medicineResearchers at Johns Hopkins University of Medicine tracked 30 organ transplant recipients who received a third dose of the COVID-19 vaccine.

They found that one-third of patients who did not have previously detectable antibodies showed increased antibody levels after the third dose. And all patients who previously showed low levels of antibody after two doses of vaccine showed high levels of antibody after the third dose.

“For everyone involved [these are] A promising finding that the defensive immunity of immunosuppressed people may ultimately be reached, “said Dr. Dolly Segev, a transplant surgeon and study author at Johns Hopkins Medicine... Although the findings are preliminary, he says, they are consistent with previous studies of how transplant recipients respond to other vaccines.

Researchers say this is the first study to report a response to a third vaccination. In this observational study, they tracked group transplant recipients who asked for a third dose on their own and tested antibody levels after dosing.

Researchers say their findings support the use of clinical trials to determine whether transplant recipients should receive the COVID-19 vaccine booster as part of standard clinical care. If the findings are reproduced in a larger study, they may affect some other types of immunocompromised patients.In fact, in France Health officials already recommend Patients with severe immunodeficiency, such as organ transplant patients and dialysis patients, receive a third dose of Pfizer or modelna vaccine.

Segev says he expects more data from France to come from France regarding the effectiveness of a third dose in immunocompromised patients.

“Obviously, all we need to learn is … who responds to the third dose,” he says. “People who need changes other than the third dose,” such as temporary changes in immunosuppressive drugs to improve the antibody response to vaccination.

Segev and his colleagues are currently seeking regulatory approval to give transplant recipients a third dose of the vaccine and initiate an intervention study that can monitor their response. They hope to be able to register participants next month or two months.

But for now, “the best we can all do for immunosuppressed people is that our normal immune system can protect vulnerable friends and family among us who have suppressed the immune system. So, get all the vaccinations, “he says.



Third dose of COVID vaccine may boost immunity of transplant recipients-WUSF public media

Source link Third dose of COVID vaccine may boost immunity of transplant recipients-WUSF public media

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