Understanding bowel inflammation may provide clues to reduce the incidence of Parkinson’s disease

According to studies by Van Andel Institute and Roche scientists, chronic inflammation of the intestine can promote the processes in the body that cause Parkinson’s disease.

Published in Free neuropathologyWith the intestines Immune system To Parkinson’s disease. Researchers’ findings in an experimental mouse model of intestinal inflammation, including several large epidemiological studies showing the association between Parkinson’s disease and inflammatory bowel disease, are as follows: Ulcerative colitis And Crohn’s disease.

Epidemiological evidence from other groups indicates the risk of developing Parkinson’s disease in certain people. Inflammatory bowel disease Is treated with anti-TNF, the standard treatment of anti-inflammatory therapy. This suggests that reducing intestinal inflammation may reduce the development of Parkinson’s disease.

“There is increasing evidence that bowel changes can affect a variety of neurological and psychiatric disorders. brain “Parkinson’s disease is a complex disease in which various factors work together to determine its onset and progression,” said Patrik Brundin, MD, Deputy Chief of Science at VAI and Kyodo News for the study. Causes .. It is necessary to understand the potential effects of the intestines on the development of Parkinson’s disease. This study provides new insights and this new knowledge can facilitate the development of improved therapeutic approaches. “

In their disease model, the team found that chronic intestinal inflammation induces a protein called. α-synuclein It aggregates not only on the walls of the colon, but also on local immune cells called macrophages. A similar process occurs in the colon of some people, such as inflammatory bowel disease, and increases the risk of developing Parkinson’s disease, as studies by other groups have shown.

Similarly, “sticky” α-synuclein aggregates also develop in the brains of patients with Parkinson’s disease. For unknown reasons, these aggregates can clog the molecular mechanisms that maintain neuronal survival. As a result, the loss of some of these important cells and the chemical mediators they produce, called dopamine, causes the characteristic movement-related symptoms of Parkinson’s disease, such as freezing and loss of voluntary movement. Further development of α-synuclein aggregates that spread throughout the brain may be associated with the non-motor symptoms of the disease and may promote progression that cannot be delayed or stopped by existing treatments.

The study also revealed the following: Chronic inflammation In older mice, α-synuclein aggregation can be exacerbated throughout the brain in the intestine during early childhood.It’s not clear exactly how this happens, but the team has two theories: First, they move inflammatory chemicals from the gut to the brain through the bloodstream, leading to protein aggregation. It suggests that it can provoke a runaway inflammatory immune response that leads to another idea: α-sinucrane aggregates Vagus nerve, One of the longest nerves in the body, is the “superhighway” between the intestines and the brain. Once there, proteins can perform toxic activity in the brain.

“We now know that the whole body system contributes to Parkinson’s disease,” said a postdoctoral fellow in Brandin’s lab, a key contributor and co-author of the study. Dr. Emmanuel Quansa said: “It was impressive to see the protein aggregation pathology of the brain, which reflects the pathology of the colon caused by inflammation. Particularly interesting observations play a major role in the development of Parkinson’s disease. It was a loss of dopamine-producing nerve cells. I had an intestinal inflammation a year and a half ago. “

In particular, the team also found that regulating immune activation in mouse models of colitis by genetic or therapeutic means regulated levels of α-synuclein clots in the colon up and down.

“Our results in mice, along with genetic and epidemiological data from other humans, provide a strong basis for further investigation of systemic immune pathways for future treatments and biomarkers of Parkinson’s disease. Shows. ”Roche Innovation Center is the section head of the Neuroscience and Rare Diseases Research Division in Basel and is the co-communication director for this study.

Findings may point to a cure for Parkinson’s disease

For more information:
Free neuropathology, DOI: 10.17879 / freeneuropathology-2021-3326

Quote: Understanding intestinal inflammation may provide clues to reduce the incidence of Parkinson’s disease (June 9, 2021) June 9, 2021, Obtained from 2021-06-gut-inflammation-clues-mitigating-parkinson.html

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Understanding bowel inflammation may provide clues to reduce the incidence of Parkinson’s disease

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