Whole body PET imaging exceeds industry standards

uEXPLORER An example of a human image of the performance of a full body PET scanner. (A) Axial slices from 18F-flucyclobin PET images (right), corresponding fusion images (center) and CT images (left) of a 68-year-old patient with castration-resistant metastatic prostate cancer. Shows a clear visualization of 18F-. Accumulation of flucicobin in lung nodules 2.5 mm in diameter. (B) Prediction of maximum intensity of representative clinical oncology 18F-FDG PET scans reconstituted with durations of 20, 5, and 2.5 minutes in 59-year-old patients with lung cancer. The image shows a primary tumor in the lower left lobe of the lung (broken circle) with multiple variable size (0.8-6 cm) phyla, mediastinum, and lower esophageal lymph node metastases (arrows) and approximately 1 cm 18FFDG- avid left adrenal nodule (arrow), which is visualized during all scan periods. Credit: Society of Nuclear Medicine and Molecular Imaging

Performance evaluations of the uEXPLORER whole body PET / CT scanner have shown that it exhibits ultra-high sensitivity that supports excellent spatial resolution and image quality. Given the long axial field of view (AFOV) of uEXPLORER, the authors of the study proposed a new extended measurement of the phantom to better characterize whole-body PET imaging. This study was published in the June issue of The. The Journal of Nuclear Medicine..

uEXPLORER is the world’s first commercially available full-body PET scanner. Since the scanner’s AFOV is 194 cm, PET data can be collected from the entire human body at the same time, greatly improving the sensitivity of the PET scanner.

The characterization of positron emission tomography (PET) scanners complies with the American Electrical Manufacturers’ Association (NEMA) NU2-2018 standard, which defines a series of experiments and analyzes using standardized imaging phantoms. This allows for a valid comparison between different PET systems. In this study, researchers used phantoms to evaluate uEXPLORER sensitivity, count rate performance, flight time resolution, and spatial resolution. image quality Accuracy of modifications based on the NEMA NU2-2018 standard. Human studies were also conducted for further characterization.

“Results on the uEXPLORERPET / CT system show a significant increase in sensitivity compared to traditional PET systems, about 15-68 times higher than other systems,” said a university biomedical engineering project. Dr. Eric Berg, a scientist, said. University of California, Davis. “We have documented excellent spatial resolution that is well supported by the increased image signal-to-noise ratio. In addition, both phantom and human image studies did not require post-reconstruction image smoothing.”

Although NEMA NU 2-2018 measurements were performed with this characterization of uEXPLORER scanner, These standards are defined only for PET scanners with an AFOV of 65 cm or less and are not suitable for long AFOV scanners such as the uEXPLORER with a length of 194 cm. As part of the study, researchers devised a series of additional informative phantom measurements to more accurately evaluate uEXPLORER for whole-body PET imaging.

“This study provides benchmarks for testing the performance of long-axis field scanners set to revolutionize the capabilities of PET scans. Understanding their performance improves scan quality. , Essential for scanning faster and with less activity, or scanning long after the injection of the radioactive tracer, “said Ramsey D., Vice-Chair of Radiology, University of California, Davis. Dr. Badawi said. “These features could be significantly improved. Patient care In addition to all areas where PET is currently used, in new areas such as autoimmune diseases, metabolic diseases, and other chronic diseases whose use has historically been ruled out due to dose considerations. ”

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For more information:
Benjamin A. Spencer et al, uEXPLORER whole body PET / CT scanner performance evaluation based on NEMA NU2-2018, additional testing for characterization of PET scanners with long axial field of view, The Journal of Nuclear Medicine (2020). DOI: 10.2967 / jnumed.120.250597

Provided by the Society of Nuclear Medicine and Molecular Imaging

Quote: Whole-body PET imaging is an industry standard (2021) acquired on July 8, 2021 from https: // July 8, 2014)

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Whole body PET imaging exceeds industry standards

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