Yogurt containing antibiotics protects against changes in the microbiome that lead to diarrhea caused by antibiotics

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Eating yogurt containing certain strains of well-studied probiotics appears to protect against adverse changes in the gut microbiota associated with antibiotic administration. This is the result of a new randomized clinical trial led by researchers at the University of Maryland at Maryland (UMSOM), the University of Maryland School of Pharmacy (UMSOP), and Georgetown University Medical Center, which was recently published in the journal. Nutrients..

Research on yogurt containing probiotics Bifidobacterium Ractis BB-12 was more effective than placebo in maintaining bacterial communities in the colon. The findings were so positive that NIH funded additional follow-up.

“This finding provides important new insights into how the probiotics BB-12 protects against antibiotic-associated diarrhea,” said Dean’s UMSOM-donated professor of medicine, co-leader of the study. One Dr. Claire Fraser said. Director of UMSOM Institute for Genomic Sciences. “The new insights gained regarding BB-12 reflect the multi-omics approach used in our study, only because of the different expertise each of the principal investigators brought to this collaborative study. It was possible. ”

In this study, 42 healthy volunteers were randomly assigned to consume a daily dose of yogurt containing BB-12, along with a standard weekly regimen of the antibiotic amoxicillin clavulanate. I did. They continued to consume yogurt daily for a week after finishing the antibiotics. An additional 20 participants acted as controls and were randomly assigned to take yogurt daily for 2 weeks without probiotics while taking the same antibiotic regimen.

Researchers found that after taking antibiotics, levels of short-chain fatty acid acetate, a beneficial metabolite produced by the microbial flora, were reduced in all subjects. However, the decrease in acetate was significantly greater in subjects receiving placebo yogurt compared to yogurt supplemented with BB-12. Acetate levels in subjects receiving BB-12 also returned to baseline levels by 30 days, but were below baseline in subjects receiving placebo.

About 1 in 5 people taking it Antibiotics Antibiotic-associated diarrhea develops because the drug disturbs health Gut microbiota.. Patients may stop taking the drug early after developing diarrhea, which may persist the original infection.A small percentage can develop life-threatening infections caused by bacteria C. Difficile, It may be present in the gut, but is usually suppressed by good bacteria in the microbiome.

“An important reason why our study may have shown positive results may be the timing of probiotic administration on the day the antibiotic was initiated by the research volunteers,” said the co-leader of the study. One Daniel Melenstein, MD, Professor of Home Medicine and Research Director, said. A program in the Department of Family Medicine, Georgetown University School of Medicine. “Starting probiotics as soon as possible before antibiotic symptoms progress can increase the chances of the probiotic mechanism developing and ultimately lead to more beneficial clinical outcomes.”

Researchers are planning a follow-up study to further investigate this question and determine the best time to consume it. Probiotics..

“This exciting clinical study was made possible by mass spectrometric-based quantification of acetate, an important endpoint for assessing the efficacy of BB-12,” he said. study Co-leader Dr. Maureen Kane, Associate Professor of Pharmaceutical Sciences, Secretary-General of the UMSOP Mass Spectrometry Center. NS Mass spectrometryA base approach to detect molecules depending on the molecule Molecular weight, Allowed accurate and accurate determination of the amount of acetate. It also enabled the measurement of several other short-chain fatty acids in biological samples obtained from patients.

“The Pharmacy Mass Spectrometry Center is providing its expertise to a variety of research and projects, demonstrating the enormous value of this technology,” said Dr. Natalie D. Edington, FAAPS, FCP, professor and dean. Says. Faculty of Pharmaceutical Sciences, University of Maryland. “Using 17 mass spectrometers, our faculty, staff and graduate students contribute to discoveries ranging from basic biology and medicine to technological development and translational research.”

“Our researchers aim to advance the treatment of patients by using advanced technology to truly understand the mechanisms behind treatment. With pharmacies in this very important project. We are pleased to work with that prominent faculty, “says E. Albert Reese. , MD, Ph.D., MBA, Executive Vice President of Healthcare at UM Baltimore, and John Z. And Akiko K. Bowers is a prominent professor and dean of the University of Maryland School of Medicine. “An interdisciplinary approach to understanding how probiotics work to maintain a healthy microbial flora advances this area and ultimately avoids the side effects that patients are debilitated by antibiotics. It’s important to help you. ”

Protecting the microbiome essential in the fight against antibiotic-resistant bacteria

For more information:
Daniel Merenstein et al, Bifidobacterium animalis subsp. Lactis BB-12 protects against antibiotic-induced functional and compositional changes in the human fecal microbiome. Nutrients (2021). DOI: 10.3390 / nu13082814

Quote: Antibiotic-containing yogurt was obtained from on September 14, 2021 for antibiotic-induced diarrhea (2021). Protects against microbiome changes leading to (September 14th)-Induction-Diarrhea.html

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Yogurt containing antibiotics protects against changes in the microbiome that lead to diarrhea caused by antibiotics

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